The disruptive SLiPPS
StrainChem’s SLiPPS (Sustainable Liquid Phase Peptide Synthesis) technology perfectly complies with the 12 principles of green chemistry.
It builds on the traditional technique developed by Nobel-prize laureate Bruce Merrifield, but it offers major improvements at three levels: economic, environmental and time-saving.
Indeed, StrainChem’s approach produces high quality peptides without involving unwanted solvents and reagents thanks to homogeneous solutions.
The key ingredient
Polyisobutylene or TAG, an industrial waste by-product, is anchored to a bifunctional substrate (S) to generate the supported substrate (TAG-S).
During the course of the following steps (n), the second function of this new compound (TAG-S) converts it into a new intermediate (TAG-In).
Then, step n+1 turns TAG-In into the supported product (TAG-P).
And finally, the target product (P) is released and the TAG is recycled.
A virtuous cycle then repeats itself until the final sequence is reached.